Published on 29 April, 2022

A vital dimension in diagnosing cellular health

Our mitochondria are key orchestrators of cellular health, responsible for our energy production, biosynthesis of cellular components, and cellular signalling.

Measuring the activity and capacity of relevant mitochondrial and cellular parameters can be of huge benefit in deciding on the appropriate protocol for a patient.

AONM is in partnership with MMD (Magdeburg Molecular Detections) in Germany. They perform a variety of extremely sophisticated and well-researched mitochondrial tests, including using extracellular flux analysis with the Seahorse XF to perform these analyses. Since its introduction in 2006, Seahorse XF technology has been used in over 7000 peer-reviewed publications.

The ATP Profile

The ATP Profile determines the total ATP production and allows for a quantitative comparison of the cells’ energy engines – mitochondria and glycolysis – in a basal state.

The Mitochondrial Health Index (MHI)

The Mitochondrial Health Index (MHI) can be used to measure improvement in mitochondrial function, and to help identify where the block to optimal functioning might lie.

Supplementary Biomarkers

Supplementary biomarkers include: Ratio of mtDNA to nDNA,  PGC-1α,  NRF-2,  Mitochondrial 4977 deletion mutant (mt4977del), and Lactate/pyruvate ratio.

How To Order Mitochondrial Tests from AONM

The tests are carried out in Germany, and the samples (1-2x CPDA S-Monovette) must be shipped on the day of the blood draw. AONM supplies the test kit and shipping documents.

Email info@aonm.org to request a test kit and instructions on how to prepare the sample.